[Home ] [Archive]   [ فارسی ]  
:: Main :: About us :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
News& Events::
Contact us::
Site Facilities::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Indexing
                        
..
:: Volume 2, Issue 7 (Winter-blood saftey supplement 2006) ::
Sci J Iran Blood Transfus Organ 2006, 2(7): 385-389 Back to browse issues page
‍Comparison of cell counter indices in differentiation of beta thalassemia minor from iron deficiency anemia
Ghafouri M. , Mostaan Sefat L. , Sharifi Sh. , Hosseini Gohari L. , Attarchi Z.
Abstract:   (58835 Views)

  Abstract

 Background and Objectives

  Distinguishing two common hypochromic microcytic anemias (i.e. iron deficiency anemia and minor thalassemia) needs expensive laboratory tests not readily available everywhere. A number of indices derived from original cell counter parameters were tried to screen patients these indices are compared in this study.

  

 Materials and Methods

  Four indices of England, Mentzer, Shine and MDHL were calculated for 110 cases of known thalassemia minors and 61 iron deficients. The best cut-off point for each index was selected by receiver operator characteristic (ROC) analysis reaching the highest sensitivity to separate thalassemics from iron deficients. Sensitivity and specificity of indices were compared.

 

 Results

  Mentzer’s index(sensitivity:90.9, specificity:80.3) had the best results.

 

 Conclusions

  It seems Mentzer’s index can be used widely to screen hypochromic microcytic anemic patients. Tests like hemoglobin electrophoresis, genetic studies, serum iron, TIBC and ferritin measurement should be reserved for selected patients in refferal centers. In this way we reduce public health costs significantly.

  

 Key words : Differential diagnosis, Minor thalassemia, Iron deficiency

Keywords: Differential diagnosis, Minor thalassemia, Iron deficiency
Full-Text [PDF 218 kb]   (29160 Downloads)    
Type of Study: Research | Subject: General
Published: 2014/08/19
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ghafouri M., Mostaan Sefat L., Sharifi Sh., Hosseini Gohari L., Attarchi Z.. ‍Comparison of cell counter indices in differentiation of beta thalassemia minor from iron deficiency anemia. Sci J Iran Blood Transfus Organ 2006; 2 (7) :385-389
URL: http://bloodjournal.ir/article-1-60-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 2, Issue 7 (Winter-blood saftey supplement 2006) Back to browse issues page
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4645