|
SLCO2B1 gene polymorphism and anti-retroviral therapy side effects in HIV-1 infected patients
|
N. Arabpoor   , Gh. Karimi  , A. Arabkhazaeli , M. Haji Abdolbaghi , M. Shahabi |
|
|
| Keywords: Key words: HIV, Therapy, Polymorphism |
|
|
Full-Text [PDF 576 kb]
(380 Downloads)
| Abstract (HTML) (567 Views)
|
Type of Study: Research |
Subject:
Infectious disease
Published: 2022/10/2
|
|
|
|
|
|
|
Full-Text: (414 Views) |
References:
- Fauci AS, Lane HA. Human Immunodeficiency Virus Disease: Aids and Related Disorders. In: Jameson JL. Harrison’s principles of internal medicine. 19th ed. Philadelphia: McGraw-Hill Education; 2018. p1273
- U.S. Department of Health and Human services. Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. 2020. Aids info. Available at: https://clinicalinfo .hiv. gov/ sites/ default/ files/ guidelines/ documents/ AdultandAdolescentGL.pdf. Accessed sep 6, 2020.
- Alam C, Whyte-Allman SK, Omeragic A, Bendayan R. Role and modulation of drug transporters in HIV-1 therapy. Adv Drug Deliv Rev 2016; 103: 121-43.
- UniProtKB-O94956(so2b1_HUMAN). 2020. Available from: https://www. uniprot. org/ uniprot/ O94956.
- Antia C, Baquerizo K, Korman A, Alikhan A, Bernstein JA. Urticaria: A comprehensive review: Treatment of chronic urticaria, special populations, and disease outcomes. J Am Acad Dermatol. 2018; 79(4): 617-33.
- Saito Y, Sawada Y, Koga Y, Sunaga N, Tsukagoshi Y, Hachisu Y, et al. Isoniazid-induced Pure Red Cell Aplasia in a Patient with Sarcoidosis: A Patient Summary and Review of the Literature. Intern Med 2017; 56(20): 2753-7.
- Piso RJ, Kriz K, Desax MC. Severe isoniazid related sideroblastic anemia. Hematol Rep 2011; 3(1): e2.
- Rao S, Murali N, Permi VD, Shetty AK. Sideroblastic Anemia Associated With Isoniazid Prophylaxis in a Person Living With HIV. Am J Ther 2020; 27(4): e409-e410
- Saito Y, Sawada Y, Koga Y, Sunaga N, Tsukagoshi Y, Hachisu Y, et al. Isoniazid-induced Pure Red Cell Aplasia in a Patient with Sarcoidosis: A Patient Summary and Review of the Literature. Intern Med 2017; 56(20): 2753-7.
- Claiborne RA, Dutt AK. Isoniazid-induced pure red cell aplasia. Am Rev Respir Dis 1985; 131(6): 947-9.
- Monaco S, Mariotto S, Ferrari S, Calabrese M, Zanusso G, Gajofatto A, et al. Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders: Advances in 2015. World J Gastroenterol 2015; 21(42): 11974-83.
- McHutchison JG, Manns MP, Brown RS, Reddy KR, Shiffman ML, Wong JB. Strategies for managing anemia in hepatitis C patients undergoing antiviral therapy. Am J Gastroenterol 2007; 102(4): 880-9.
- McHutchison JG, Manns MP, Longo DL. Definition and management of anemia in patients infected with hepatitis C virus. Liver Int 2006; 26(4): 389-98.
- Sulkowski MS, Benhamou Y. Therapeutic issues in HIV/HCV-coinfected patients. J Viral Hepat 2007; 14(6): 371-86.
- American Psychiatric Association, DSM-5 Task Force. 5th ed. American Psychiatric Publishing, Inc, 2013. p. 348.
|
Sci J Iran Blood Transfus Organ 2022;19 (3): 183-190
|
SLCO2B1 gene polymorphism and anti-retroviral
therapy side effects in HIV-1 infected patients
Arabpour N.1, Karimi Gh.1, Arabkhazaeli A.1, Haji Abdolbaghi M.2, Shahabi M.1
1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
2Department of Infectious Diseases and Tropical Medicine, Imam Khomeini Hospital complex, Tehran University of Medical Sciences, Tehran, Iran
Abstract
Background and Objectives
HIV virus and its subsequent disease is one of the most important challenges of the world health system. Although antiretroviral therapy (ART) is a breakthrough in patients’ life quality, it has complications like side effects. The side effect causes are diverse. One of the factors considered about side effects is genes polymorphism. This study investigates the relationship between rs2712816 and rs949096 polymorphisms on SLCO2B1 gene which is one of the most important antiretroviral drugs transporters.
Materials and Methods
In this Cross-sectional study, the two variants, rs2712816 and rs949069 were genotyped on 161 samples of HIV-1 infected patients. Consequently, the records of patients in Imam Khomeini Behavioral Diseases Center were reviewed and necessary data were collected. Statistical analysis was done by chi-square, exact Fisher test, and Mann Whitney U test using SPSS 26.0.
Results
The results show that there is a significant relationship between AA genotype in rs949069 polymorphism and dizziness and urticaria in patients (p< 0.05). The rs2712816 polymorphism and side effects did not show any significant relationship.
Conclusions
There are different factors involved in antiretroviral therapy side effects. According to the results of this study, the rs949069 is one of the factors.
Key words: HIV, Therapy, Polymorphism
Received: 23 Sep 2020
Accepted: 24 Apr 2022
Correspondence: Shahabi M., PhD of Biological Products. Assistant professor of Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine.
P.O.Box: 14665-1157, Tehran, Iran. Tel: (+9821) 88601558; Fax: (+9821) 88601542
E-mail: m.shahabi@tmi.ac.ir
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Arabpoor N, Karimi G, Arabkhazaeli A, Haji Abdolbaghi M, Shahabi M. SLCO2B1 gene polymorphism and anti-retroviral therapy side effects in HIV-1 infected patients. Sci J Iran Blood Transfus Organ 2022; 19 (3) :183-190 URL: http://bloodjournal.ir/article-1-1374-en.html
|
.jpg)
.png)
