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:: Volume 2, Number 7 (Winter-blood saftey supplement 2006) ::
Back to browse issues page 2006, 2(7): 385-389
XML ‍Comparison of cell counter indices in differentiation of beta thalassemia minor from iron deficiency anemia Print

Persian Abstract
Author(s): Ghafouri M. , Mostaan Sefat L., Sharifi Sh., Hosseini Gohari L. , Attarchi Z.
Study Type: Research | Subject: General
Article abstract:


 Background and Objectives

  Distinguishing two common hypochromic microcytic anemias (i.e. iron deficiency anemia and minor thalassemia) needs expensive laboratory tests not readily available everywhere. A number of indices derived from original cell counter parameters were tried to screen patients these indices are compared in this study.


 Materials and Methods

  Four indices of England, Mentzer, Shine and MDHL were calculated for 110 cases of known thalassemia minors and 61 iron deficients. The best cut-off point for each index was selected by receiver operator characteristic (ROC) analysis reaching the highest sensitivity to separate thalassemics from iron deficients. Sensitivity and specificity of indices were compared.



  Mentzer’s index(sensitivity:90.9, specificity:80.3) had the best results.



  It seems Mentzer’s index can be used widely to screen hypochromic microcytic anemic patients. Tests like hemoglobin electrophoresis, genetic studies, serum iron, TIBC and ferritin measurement should be reserved for selected patients in refferal centers. In this way we reduce public health costs significantly.


 Key words : Differential diagnosis, Minor thalassemia, Iron deficiency

KeywordsDifferential diagnosis, Minor thalassemia, Iron deficiency,
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Ghafouri M. , Mostaan Sefat L. , Sharifi Sh. , Hosseini Gohari L. , Attarchi Z. . ‍Comparison of cell counter indices in differentiation of beta thalassemia minor from iron deficiency anemia. Sci J Blood Transfus Organ. 2006; 2 (7) :385-389
URL http://www.bloodjournal.ir/browse.php?a_code=A-10-1-58&slc_lang=en&sid=1
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Back to browse issues page Volume 2, Number 7 ( Winter-blood saftey supplement 2006)
فصلنامه پژوهشي خون Sci J Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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