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:: Volume 2, Number 7 (Winter-blood saftey supplement 2006) ::
Back to browse issues page 2006, 2(7): 385-389
‍Comparison of cell counter indices in differentiation of beta thalassemia minor from iron deficiency anemia
Ghafouri M. *, Mostaan Sefat L., Sharifi Sh., Hosseini Gohari L. , Attarchi Z.
Abstract:   (29687 View)

  Abstract

 Background and Objectives

  Distinguishing two common hypochromic microcytic anemias (i.e. iron deficiency anemia and minor thalassemia) needs expensive laboratory tests not readily available everywhere. A number of indices derived from original cell counter parameters were tried to screen patients these indices are compared in this study.

  

 Materials and Methods

  Four indices of England, Mentzer, Shine and MDHL were calculated for 110 cases of known thalassemia minors and 61 iron deficients. The best cut-off point for each index was selected by receiver operator characteristic (ROC) analysis reaching the highest sensitivity to separate thalassemics from iron deficients. Sensitivity and specificity of indices were compared.

 

 Results

  Mentzer’s index(sensitivity:90.9, specificity:80.3) had the best results.

 

 Conclusions

  It seems Mentzer’s index can be used widely to screen hypochromic microcytic anemic patients. Tests like hemoglobin electrophoresis, genetic studies, serum iron, TIBC and ferritin measurement should be reserved for selected patients in refferal centers. In this way we reduce public health costs significantly.

  

 Key words : Differential diagnosis, Minor thalassemia, Iron deficiency

Keywords: Differential diagnosis, Minor thalassemia, Iron deficiency,
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Type of Study: Research | Subject: General
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Ghafouri M., Mostaan Sefat L., Sharifi Sh., Hosseini Gohari L., Attarchi Z.. ‍Comparison of cell counter indices in differentiation of beta thalassemia minor from iron deficiency anemia. Scientific Journal of Iran Blood Transfus Organ. 2006; 2 (7) :385-389
URL: http://www.bloodjournal.ir/article-1-60-en.html
Back to browse issues page Volume 2, Number 7 (Winter-blood saftey supplement 2006)
فصلنامه پژوهشی خون Scientific Journal of Iran Blood Transfus Organ
The Scientific Journal of Iranian Blood Transfusion Organization - Copyright 2006 by IBTO
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